Everything about Goblet Cell totally explained
Goblet cells are
glandular simple columnar
epithelial cells whose sole function is to secrete
mucus. They secrete using both
apocrine and
merocrine methods of secretion.
The majority of the cell's cytoplasm is occupied by mucinogen granules, except at the bottom. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects
microvilli to increase surface area for secretion.
Locations
They are found scattered among the epithelial lining of many organs, especially the
intestinal and
respiratory tracts. In the respiratory tract, they're found inside the
trachea,
bronchus, and larger
bronchioles.
Histology
In
mucicarmine stains, goblet cells can be easily identified by the deep red mucin found within their cell bodies.
The
nuclei of goblet cells tend to be displaced toward the basal end of the cell body, close to
basement membrane, leading to intense basophilic staining.
Etymology
The term
goblet refers to these cells' goblet-like shape. The apical portion is shaped like a cup, as it's distended by abundant mucinogen granules; its basal portion is shaped like a stem, as it's narrow for lack of these granules.
There are other cells which secrete mucus (as in the
fundic glands of the
stomach), but they're not usually called "goblet cells" because they don't have this distinctive shape.
Basal secretion
This is the normal base level secretion of mucus. The continuous secretion is accomplished by
cytoskeletal movement of
secretory granules.
Stimulated secretion
Secretion may be stimulated by
dust,
smoke, etc.
Other stimuli include viruses, bacteria, etc.
Additional images
Image:Gray1062.png|An intestinal gland from the human intestine.
Image:Gobletcel.jpg|Goblet cell in ileum
Further Information
Get more info on 'Goblet Cell'.
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